Premium
No beneficial effect of splenectomy in hereditary high red cell membrane phosphatidylcholine hemolytic anemia: Clinical and membrane studies of 20 patients
Author(s) -
Otsuka Akiyo,
Sugihara Takashi,
Yawata Yoshihito
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830340104
Subject(s) - splenectomy , hemolysis , medicine , hemolytic anemia , red cell , anemia , hematology , red blood cell , erythrocyte membrane , gastroenterology , hereditary spherocytosis , immunology , spleen , chemistry , membrane , biochemistry
The clinical features and red cell membrane characteristics of 20 patients with hereditary high red cell membrane phosphatidylcholine hemolytic anemia (HPCHA) were studied in relation to the effect of splenectomy. After splenectomy, anemia worsened and the extent of increased hemolysis in these patients was unchanged, indicating a contraindication for splenectomy. Concomitant with these results in clinical hematology, marked stomatocytic changes, increased red cell phosphatidylcholine content, and enhanced sodium transport, which were observed before splenectomy, were not improved by splenectomy.