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Platelet peroxidase‐like activity detected in mature erythroblasts from a patient with pernicious anemia
Author(s) -
Kawaguchi Masato,
Nakano Masaru,
Enomoto Yasuhiro,
Watanabe Younosuke,
Toyama Keisuke
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830330410
Subject(s) - pernicious anemia , clone (java method) , bone marrow , peroxidase , anemia , platelet , population , immunology , lineage (genetic) , biology , medicine , enzyme , biochemistry , gene , environmental health
We report a case of pernicious anemia in which the possession of platelet peroxidase (PPO)‐like activity was proved in its erythroblasts. PPO‐positive cells were found in a distinct minor population of hemoglobinized (as a mean of differentiated) erythroid cells in the bone marrow before treatment, but these cells disappeared following therapy with vitamin B 12 . The present report is considered to be the first case to identify PPO‐like activity in mature erythroblasts from the nonmalignant clone. The existence of PPO in erythroid lineage in cases with pernicious anemia is discussed.