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Hematological abnormalities in hemophilic patients with human immunodeficiency virus infection
Author(s) -
Bello Jose L.,
Burgaleta Carmen,
Magallon Manuel,
Herruzo Rafael,
Villar Jose M.
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830330403
Subject(s) - leukopenia , hemophagocytosis , medicine , bone marrow , lymphocytosis , anemia , immunology , coagulopathy , immunopathology , aids related complex , viral disease , human immunodeficiency virus (hiv) , pathology , pancytopenia , chemotherapy
Hematological abnormalities are common in patients with AIDS or AIDS‐related complex. We studied cytological characteristics in peripheral blood and bone marrow samples of 33 hemophilic patients with HIV Infection and in six HIV negatives. The HIV‐positive patients presented leukopenia (60.6%), thrombocytopenia (69.9%), and anemia (57.5%). Bone marrow showed abnormalities of maturation in one or more cell lines similar to those described in other HIV‐infected groups of patients. These findings were more prominent in megacaryocytes and granulocytic series. Lymphocytosis, plasmocytosis, and increased hemophagocytosis were also common. These alterations do not appear in HIV‐negative patients and seem related to a direct effect of HIV on bone marrow cells or to alterations in T‐cell regulatory functions.