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Prevalence of a shortened prostacyclin half‐life in plasma in healthy adults: Results of a screening investigation
Author(s) -
Sinzinger H.,
Rauscha F.,
Fitscha P.,
Granegger Susanne
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830330212
Subject(s) - prostacyclin , medicine
Out of a total of 1,981 adults (956 males, 1,025 females; aged 16‐71 yr) undergoing a screening investigation for elevated cholesterol only 3 healthy participants with pathologically enhanced prostaglandin 12 (PG12) degradation in plasma in vitro were discovered. The PG12 half‐life in these three screenings was shorter than 60 sec and persisted during several follow‐up checks. In one patient a familial defect was discovered. Diseases known to be associated with this disturbance in PG12 metabolism have been excluded. The mean half‐life of PG12 in 1,978 people amounted to 10.71 ± 1.93 min. It still needs to be clarified whether this rare disturbance in PG12 metabolism is causally related to, or only associated with, thromboembolic events. A possible predisposition should be elucidated by regular monitoring of affected persons.