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Thrombocytopenic purpura in a patient with lupus anticoagulant: Requirement of both immunosuppressive and antithrombotic therapies
Author(s) -
Iwahara Yoshihito,
Niiya Kenji,
Yamato Kenji,
Miyoshi Lsao
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830330116
Subject(s) - medicine , antithrombotic , thrombosis , thrombocytopenic purpura , thrombotic thrombocytopenic purpura , aspirin , lupus anticoagulant , warfarin , prednisolone , venous thrombosis , anticoagulant , systemic lupus erythematosus , purpura (gastropod) , platelet , surgery , atrial fibrillation , ecology , disease , biology
A 33 year old woman with severe thrombocytopenic purpura complicated by typical lupus anticoagulant developed repeated spontaneous abortion, deep venous thrombosis, and cerebral thrombosis. The platelet count fluctuated from 4,000 to 400,000/mm 3 during the 13 year clinical course. The physical and laboratory findings at the time of severe thrombocytopenic purpure were compatible with the criteria of idiopathic thrombocytopenic purpura except for positive lupus anticoagulant. Both immunosuppressive therapy with prednisolone and antithrombotic therapy with warfarin and aspirin were necessary for the control of bleeding and venous and arterial thrombosis.