Premium
Transient engraftment of syngeneic bone marrow after conditioning with high‐dose cyclophosphamide and thoracoabdominal irradiation in a patient with aplastic anemia
Author(s) -
Matsue Kosei,
Niki Takeo,
Shiobara Shintaro,
Ueda Mikio,
Ohtake Shigeki,
Mori Takao,
Matsuda Tamotsu,
Harada Mine
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830330111
Subject(s) - medicine , cyclophosphamide , aplastic anemia , bone marrow , immunosuppression , bone marrow failure , anemia , total body irradiation , transplantation , surgery , immunology , haematopoiesis , chemotherapy , stem cell , biology , genetics
We describe the clinical course of a 16 year old girl with aplastic anemia who was treated by syngeneic bone marrow transplantation. Engraftment was not obtained by simple infusion of bone marrow without immunosuppression. The patient received a high‐dose cyclophosphamide and thoracoabdominal irradiation, followed by second marrow transplantation from the same donor. Incomplete but significant hematologic recovery was observed; however, marrow failure recurred 5 months after transplantation. Since donor and recipient pairs were genotypically identical, graft failure could not be attributed to immunological reactivity of recipient cells to donor non‐HLA antigens. This case report implies that graft failure in some cases of aplastic anemia might be mediated by inhibitory cells resistant to cyclophosphamide and irradiation.