Premium
Chromosomal abnormalities define clonal proliferation in CD3‐ large granular lymphocyte leukemia
Author(s) -
Taniwaki Masafumi,
Tagawa Shinichi,
Nishigaki Hikari,
Horiike Shigeo,
Misawa Shinichi,
Shimazaki Chihiro,
Maekawa Taira,
Fujii Hiroshi,
Kitani Teruo,
Abe Tatsuo
Publication year - 1990
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830330107
Subject(s) - cd3 , hepatosplenomegaly , biology , lymphoproliferative disorders , phenotype , clone (java method) , lymphocyte , immunology , t cell receptor , gene rearrangement , pathology , t cell , antigen , lymphoma , gene , genetics , disease , medicine , immune system , cd8
Six patients with lymphoproliferative disorder of large granular lymphocytes (LDGL) were studied for chromosomal abnormalities. When the patients were divided into two groups depending on the expression of a mature antigen of T cell lineage, CD3, two with CD3 + phenotype had a stable disease, whereas three of the four patients with CD3‐ phenotype had marked hepatosplenomegaly and a highly aggressive disease. Chromosomal abnormalities were detected in four of six patients, indicating a clonal proliferation of large granular lymphocytes in individual patients. In particular, chromosomal abnormalities were found in three of the four patients with CD3‐ LDGL. all of which had a germ‐line configuration of the T cell receptor beta‐chain gene. Thus, the chromosomal abnormalities provide definitive evidence for the clonal origin of the expanded cells in the CD3‐LDGL.