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Horner's syndrome and demyelinating peripheral neuropathy caused by high‐dose cytosine arabinoside
Author(s) -
Nevill T. J.,
Benstead T. J.,
McCormick C. W.,
Hayne O. A.
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830320414
Subject(s) - cytosine , medicine , peripheral neuropathy , cytarabine , leukemia , peripheral , peripheral nervous system , refractory (planetary science) , complication , gastroenterology , central nervous system , endocrinology , chemistry , biology , dna , astrobiology , diabetes mellitus , biochemistry
High‐dose cytosine arabinoside may benefit patients with refractory acute leukemia. Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported. We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving highdose cytosine arabinoside. Peripheral nerve dysfunction is a potentially serious complication of high‐dose cytosine arabinoside.