Horner's syndrome and demyelinating peripheral neuropathy caused by high‐dose cytosine arabinoside | Zendy

Nevill T. J. | Zendy; Benstead T. J. | Zendy; McCormick C. W. | Zendy; Hayne O. A. | Zendy

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Horner's syndrome and demyelinating peripheral neuropathy caused by high‐dose cytosine arabinoside

Author(s) -

Nevill T. J.,

Benstead T. J.,

McCormick C. W.,

Hayne O. A.

Publication year - 1989

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830320414

Subject(s) - cytosine , medicine , peripheral neuropathy , cytarabine , leukemia , peripheral , peripheral nervous system , refractory (planetary science) , complication , gastroenterology , central nervous system , endocrinology , chemistry , biology , dna , astrobiology , diabetes mellitus , biochemistry

High‐dose cytosine arabinoside may benefit patients with refractory acute leukemia. Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported. We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving highdose cytosine arabinoside. Peripheral nerve dysfunction is a potentially serious complication of high‐dose cytosine arabinoside.

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