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Case report: Allergic reaction with immune hemolytic anemia resulting from chlorambucil
Author(s) -
ThompsonMoya Luis,
Martin Thomas,
Heuft HansGert,
Neubauer Andreas,
Herrmann Richard
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830320314
Subject(s) - chlorambucil , hemolysis , hemolytic anemia , medicine , immunology , immune system , anemia , chronic lymphocytic leukemia , allergy , leukemia , chemotherapy , cyclophosphamide
In a 73‐year‐old female with chronic lymphocytic leukemia we observed an acute illness with shivering, high fever, and hemolytic anemia following chlorambucil administration. Reexposure in a controlled clinical situation suggested an allergic drug reaction. In an in vitro assay, we were able to demonstrate chlorambucil as the causative agent of immune hemolysis.