Premium
Bone marrow aplasia associated with proliferation of large granular lymphocytes and subsequent transformation to acute lymphoblastic leukemia
Author(s) -
Schiller Gary J.,
Naeim Faramarz,
Champlin Richard E.
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830320217
Subject(s) - aplastic anemia , neutropenia , immunology , bone marrow aplasia , phenotype , medicine , lymphoblastic leukemia , bone marrow , aplasia , leukemia , cancer research , biology , gene , chemotherapy , biochemistry
Proliferation of large granular lymphocytes may be associated with neutropenia and, less frequently, thrombocytopenia. In this report, we describe a patient with severe aplastic anemia in the setting of a proliferation of cells with natural killer (NK) phenotype. We demonstrated evolution to acute lymphoblastic leukemia by cells of identical phenotype.