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Hodgkin disease in a patient with common variable immunodeficiency
Author(s) -
Fesus Susan M.,
Hagemeister Fredrick B.,
Manning John
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830320212
Subject(s) - hypogammaglobulinemia , common variable immunodeficiency , immunodeficiency , disease , medicine , primary immunodeficiency , immunology , toxic shock syndrome , immunopathology , immunodeficiency syndrome , chemotherapy , immune system , antibody , biology , bacteria , genetics , staphylococcus aureus
Extensive extralymphatic Hodgkin disease developed in a young man with common variable immunodeficiency manifested by hypogammaglobulinemia, recurrent sinopulmonary infections, and multiple autoimmune phenomena. Both humoral and cell‐mediated immune dysfunction were present prior to treatment. After two cycles of chemotherapy, irreversible shock developed, and death occurred secondary to overwhelming infection in spite of prophylactic gammaglobuiin replacement. The unusual features of this patient's case of extralymphatic Hodgkin disease in association with a primary immunodeficiency disorder have not been previously reported.