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Acute nonlymphocytic leukemia with basophilic differentiation and t(9,11)(p22,q23) in a child
Author(s) -
Kubota Masaru,
Akiyama Yuichi,
Tabata Yasuyuki,
Yoshigi Masaaki,
Mikawa Haruki
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830310213
Subject(s) - basophilic , leukemia , medicine , pathology
A 20‐month‐old child was treated for acute nonlymphocytic leukemia (ANLL) with basophilic differentiation. His leukemic cells also had the cytogenetic abnormality of t(9,11)(p22,q23). Although immature blasts responded well to induction therapy with etoposide, the leukemic cells that were more differentiated toward basophils were quite refractory to the drug. However, complete remission was finally achieved with a conventional multidrug regimen.