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Myelodysplastic syndrome with trisomy 11 associated with polycythemia vera
Author(s) -
Ohyashiki Kazuma,
Nagasu Masaya,
Hojo Hitoshi,
Iwabuchi Atsuhiro,
Ohyashiki Junko H.,
Toyama Keisuke
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830310209
Subject(s) - polycythemia vera , trisomy , myelodysplastic syndromes , medicine , immunology , genetics , biology , bone marrow
A 52‐year‐old male with myelodysplastic syndrome (MDS) who had a prior history of polycythemia vera is reported. Chromosome analysis revealed that the bone marrow and blood cells at the MDS phase contained trisomy of chromosome 11 as the sole cytogenetic change. Trisomy 11 is rarely found in hematologic neoplasia, and all of the reported cases with trisomy 11 were diagnosed as having nonlymphocytic neoplasia. In this report, a correlation between the chromosome change and leukemia/MDS developed in polycythemia vera is discussed.