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Heparin cofactor II in adults and infants with thrombosis and DIC
Author(s) -
Chuansumrit Ampaiwan,
MancoJohnson Marilyn J.,
Hathaway William E.
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830310207
Subject(s) - heparin cofactor ii , medicine , coagulopathy , gestational age , gastroenterology , heparin , thrombosis , reference range , protein c , pediatrics , pregnancy , antithrombin , biology , genetics
Heparin cofactor II (HC II) was measured by a chromogenic activity assay in normal preterm infants (gestational age, 28–36 weeks; n = 17; 29% ± 11.5 [mean ± 1 SD], range 11–51), normal full‐term infants (n = 18; 49% ± 6.6 [mean ± 1 SD], range 36–58), and normal adults (n = 38; 101% ± 14 [mean ± 1 SD], range 73–130). Normal children attained adult levels at approximately 5 to 7 months of age. The lower values in preterm and term infants most likely reflect immature liver function. Neither adults and children with a history of thrombosis with prior negative evaluation (n = 74), patients with documented protein C and protein S deficiency (n = 4), nor sick infants without evidence of consumptive coagulopathy (n = 15) had significantly lower levels of HC II activity. Infants with disseminated intravascular coagulation (n = 2) had strikingly lower levels of HC II activity.