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Pseudothrombocytopenia induced by a monoclonal IgM kappa platelet agglutinin
Author(s) -
Hoyt Robert H.,
Durie Brian G. M.
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830310110
Subject(s) - cold agglutinin , platelet , agglutination (biology) , kappa , medicine , monoclonal , immunology , monoclonal antibody , pathology , antibody , philosophy , linguistics
Pseudothrombocytopenia is an in vitro phenomenon usually associated with anticoagulant (EDTA)‐dependent IgG platelet agglutinins. A low Coulter platelet count was investigated in a 63‐year‐old woman with multiple sclerosis and a monoclonal IgM kappa gammopathy. An unusual type of EDTA‐ and temperature‐independent IgM platelet agglutinin was identified by in vitro agglutination of donor platelets and was removed by immunoabsorption.