Premium
Long‐term effect of splenectomy on transfusion requirements in thalassemia major
Author(s) -
Cohen Alan,
Gayer Robin,
Mizanin Jeannie
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830300412
Subject(s) - splenectomy , medicine , thalassemia , blood transfusion , surgery , spleen
Splenectomy reduces transfusion requirements in the first year after surgery in patients with thalassemia major and hypersplenism. To determine whether this response is maintained, we have studied transfusion requirements in 16 patients with thalassemia major for 2–17 years after splenectomy. Transfusion requirements remained stable (mean yearly change ‐0.1%) after the predictable fall in the first year after surgery. The mean change between the first postoperative year and the most recent year was ‐7 ml/kg. Transfusion requirements and the magnitude of change from year to year were unrelated to the time since splenectomy. These studies indicate that the effect of splenectomy on transfusion requirements is long‐lasting and that large variations in annual transfusion requirements after splenectomy should prompt a search for accessory spleens or other causes of red cell destruction.