Premium
Splenic irradiation as primary therapy for prolymphocytic leukemia
Author(s) -
Kiss A.,
Haubenstock A.,
Bognar H.,
Scheiderbauer R.,
AiMobarak M.,
Base W.
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830300313
Subject(s) - prolymphocytic leukemia , medicine , stage (stratigraphy) , leukemia , oncology , chronic lymphocytic leukemia , biology , paleontology
A patient with prolymphocytic leukemia (PLL), a lymphoproliferative disorder that carries a poor prognosis, is presented. The disease was diagnosed at an early stage and treatment could be delayed for four years. When massive, painful splenomegaly developed, splenic irradiation (SI) was chosen as the primary form of therapy and an excellent systemic response could be achieved. Our observation is in agreement with preliminary studies, which advocate SI as the primary form of therapy in PLL. Furthermore, it is emphasized that an early diagnosis of PLL is necessary to establish its true course and that the prognosis may be better than originally thought.