Premium
Factor VIII inhibitor in insulin‐dependent diabetes mellitus
Author(s) -
Wajima Takeshi,
Hall Gregory
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830300312
Subject(s) - medicine , diabetes mellitus , hemostasis , coagulation , endocrinology , antibody , insulin , titer , gastroenterology , immunology
Abstract Acquired factor VIII inhibitor was found in a 69‐year‐old white male with insulin‐dependent diabetes mellitus. He presented with left lower abdominal pain and hematoma after a fall. Preoperative hemostasis studies were normal except for prolonged aPTT. Prolonged aPTT was not corrected by 1:1 mixture with normal fresh plasma and incubation showed further prolongation with time. Factor VIII:c was 3.5%. The inhibitor titer was 7.5 Bethesda units. The possible mechanism causing antibody to factor VIII was postulated to be an autoimmune process and/or increased immunogenicity owing to glycosy‐lation of factor VIII coagulant protein.