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Primary lymph node presentation of angiocentric lymphoma associated with features of a hemophagocytic syndrome
Author(s) -
Kueck Brian D.,
Hanson Curtis A.,
Weissman David E.,
Bayliss Katherine
Publication year - 1989
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830300210
Subject(s) - medicine , lymphoma , lymph node , presentation (obstetrics) , pathology , immunology , surgery
The spectrum of post‐thymic T‐cell neoplasia includes the angiocentric immunoproliterative lesions, a group of disorders histologically exhibiting vascular infiltration and destruction; included among these disorders is angiocentric lymphoma. In contrast to the typical extranodal presentation seen in the angiocentric immunoproiiferative lesions, this report describes a case of angiocentric lymphoma presenting as primary lymph node disease with clinicopathologic findings mimicking a hemophagocytic syndrome. Rearrangement of the T‐cell receptor beta chain documents this case to be a clonal T‐cell neoplasm. The association of this distinct histologic type of T‐cell malignancy with hemophagocytic syndromes is reviewed.