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Daily exposure to forty percent oxygen causes a decrease in platelet count
Author(s) -
Meintjes André F.,
Baynes Roy D.,
Rogers Geoff G.,
Mendelow Barry V.
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830290405
Subject(s) - platelet , medicine , room air distribution , oxygen , zoology , chemistry , biology , physics , organic chemistry , thermodynamics
A study was undertaken to evaluate a previous observation made in this laboratory that hyperoxic treadmill training is associated with a decrease in the circulating platelet count (PLT). The subjects studied breathed air containing 40% oxygen for 30 min/day, 5 days/week, for 6 weeks, while at rest in the seated position. Such exposure resulted in a consistent fall in PLT between day 1 and day 5 of each week ( P < .01). In addition, there was a progressive decline in PLT over the 6 weeks of exposure to the hyperoxic air, PLT being inversely correlated with the duration of hyperoxic exposure (r s = ‐0.886, P < .02). The total decrease in PLT over the 6 weeks was 56 ± 46 ± 10 9 I −1 ( P < .025). Not surprisingly, these changes were mirrored in the plateletcrit (Pct). The decrease in PLT did not appear to be secondary to either hemodilution or reduced erythropoietic stimulation. The mechanism of production and the biological significance of these changes remain to be elucidated.