Premium
Probable genetic linkage between genes coding for platelet‐specific antigens of the PI A and bak systems
Author(s) -
Letellier Steven J.,
Hunter Jay B.,
Aster Richard H.
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830290304
Subject(s) - antigen , gene , platelet , thrombasthenia , pi , glycoprotein , biology , platelet membrane glycoprotein , genetic linkage , glanzmann's thrombasthenia , genetics , inheritance (genetic algorithm) , immunology , microbiology and biotechnology , biochemistry , platelet aggregation
Studies of the inheritance of the platelet‐specific alloantigens PI A1 /Pl A2 and Bak a /Bak b in informative families provided evidence that the genes determining Pl A and Bak antigens are in close genetic linkage ( P = .004). In 154 normal, unrelated Caucasian subjects it was found that the antigen PI A1 is associated with Bak a and the antigen PI A2 with Bak b more often than would be expected by chance ( P < .05). Bak and PI A antigens are carried on platelet membrane glycoproteins IIb and IIIa, respectively, which are decreased or absent in the inherited platelet disorder Glazmann's thrombasthenia. Thus, the findings suggest that the defect in this disease involves two closely linked genes.