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Evidence for posttranslational control of fetal hemoglobin synthesis
Author(s) -
Qiu C. C.,
Abraham E. C.
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830290116
Subject(s) - fetal hemoglobin , protein subunit , hemoglobin , chemistry , thalassemia , fetus , competition (biology) , hemoglobinopathy , biochemistry , medicine , biology , genetics , pregnancy , hemolytic anemia , gene , ecology
Abstract Subunit competition experiments were conducted by recombining various amounts of α‐subunits with an equimolar mixture of γ‐and β A ‐subunits. The results showed that γ‐subunits combine with α‐subunits less readily than β‐subunits. Thus, in the presence of α‐chain deficiency (α‐thalassemia) the formation of HbA is preferred over HbF, resulting in a decrease in the level of the latter.