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Acute lymphoblastic leukemia in a patient with longstanding polycythemia vera: Cytogenetic analysis reveals two distinct abnormal clones
Author(s) -
Anastasi John,
Pettenati Mark J.,
Le Beau Michelle M.,
Kwaan Hau C.,
Weil Susan C.
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830290108
Subject(s) - polycythemia vera , chromosomal abnormality , lymphoproliferative disorders , medicine , lymphoblastic leukemia , polycythemia rubra vera , abnormality , karyotype , immunology , somatic evolution in cancer , acute leukemia , pathology , leukemia , cytogenetics , chromosome , biology , genetics , lymphoma , cancer , gene , psychiatry
A 68‐year‐old female patient is described in whom acute lymphoblastic leukemia followed a long course of polycythemia vera. Chromosomal analysis of a peripheral blood specimen at the time of blastic transformation revealed two distinct clones: one characterized by a chromosomal abnormality frequently noted in polycythemia vera and the other by a rearrangement characteristically observed in lymphoid malignancies. These findings suggest the existence of two independent hematologic diseases: this phenomenon would not support the speculation from previous reports that lymphoproliferative disorders in patients with polycythemia vera arise from clonal evolution.