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Successful outcome of severe aplastic anemia following epstein‐barr virus infection
Author(s) -
Grishaber Judy E.,
McClain Kenneth L.,
Mahoney Donald H.,
Fernbach Donald J.
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830280412
Subject(s) - aplastic anemia , medicine , prednisone , immunology , anemia , virus , pathophysiology , bone marrow , disease , bone marrow failure , epstein–barr virus , haematopoiesis , stem cell , biology , genetics
Severe aplastic anemia has been reported in children following Epstein‐Barr virus (EBV) infection. The pathophysiology of disease is not known, but an immunologic mechanism is suspected because of the rapid response to steroids. A patient with severe aplastic anemia following EBV infection experienced bone marrow recovery after treatment with high‐dose prednisone. After reviewing the literature it is concluded that steroid therapy is indicated in this select group of patients.