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Significance and limits of cerebrospinal fluid beta‐2‐microglobulin measurement in course of acute lymphoblastic leukemia
Author(s) -
Musto Pellegrino,
Tomasi Paolo,
Cascavilla Nicola,
Ladogana Saverio,
La Sala Antonio,
Melillo Lorella,
Nobile Michele,
Castoldi Gianluigi,
Carotenuto Mario
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830280402
Subject(s) - beta 2 microglobulin , lymphoblastic leukemia , cerebrospinal fluid , medicine , beta (programming language) , leukemia , immunology , computer science , programming language
Abstract Cerebrospinal fluid beta‐2‐microglobulin (CSF‐β2m) was measured longitudinally in 48 patients affected by acute lymphoblastic leukemia (ALL). Thirteen developed a central nervous system (CNS) involvement during the course of the disease; although moderately higher mean CSF‐β2m levels were found in these subjects, no significant statistical differences were observed in comparison with patients without this complication and compared with the control group. No correlations were found between β2m and other biochemical parameters in CSF. Furthermore, CSF‐β2m levels appeared to be influenced by previous combined chemoradiotherapeutic treatment for CNS prophylaxis, presence of meningeal non‐neoplastic infiltrates, patients' ages, amount of CSF blasts, and their immunological phenotype. In particular, only clearly B‐committed leukemic cells, when tested, showed a strong surface expression of β2m, as demonstrated by immunocytochemical detection of this protein on cell membrane. However, in specific cases, CSF β2m measurement and CSF/serum β2m ratio were helpful in diagnosing and monitoring isolated CNS disease. Such findings suggest that CSF‐β2m assay may be a useful tool in the management of CNS involvement in the course of ALL in only selected patients, as several factors can modify the outcome.