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Acute promyelocytic leukemia presenting as sudden blindness and sinus vein thrombosis
Author(s) -
Hazani Anna,
Weidenfeld Yaakov,
Tatarsky Llana,
Bental Efraim
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830280112
Subject(s) - medicine , acute promyelocytic leukemia , disseminated intravascular coagulation , thrombosis , leukemia , blindness , deep vein , acute leukemia , surgery , retinoic acid , optometry , biochemistry , chemistry , gene
An 11‐year‐old boy was hospitalized with sudden blindness and sagittal sinus vein thrombosis, which were the presenting signs of acute promyelocytic leukemia (APL). The association of disseminated intravascular clotting (DIC) with APL is well‐known, and DIC usually affects the smaller blood vessels. The obliteration of a large blood vessel, as in our case, is an uncommon manifestation of DIC. This presentation of acute childhood leukemia is unusual and, to the best of our knowledge, has not been previously reported.