Premium
Asymptomatic association of hemoglobin Dunn (α6[A4]Asp→Asn) and hemoglobin O‐Arab (β121[GH4]Glu→Lys) in a Moroccan man
Author(s) -
Baklouti Faouzi,
Francina Alain,
Dorléac Evelyne,
BaudinChich Véronique,
GombaudSaintonge Germaine,
Plauchu Henri,
Wajcman Henri,
Delaunay Jean,
Godet Jacqueline
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830270405
Subject(s) - hemoglobin , exon , asymptomatic , gene , mutation , genetics , microbiology and biotechnology , hemoglobin variants , point mutation , amino acid substitution , biology , medicine , biochemistry
Abstract We report on the association of Hb Dunn (α6[A4]Asp→Asn) and Hb O‐Arab (β121[GH4]Glu→Lys) in a healthy Moroccan man. Hb Dunn had the same electrophoretic properties as Hb G‐Philadelphia, but its percentage was lower. Its identification was based on sequence determination of the αT1 peptide. Bgl II and Eco RI mapping showed the presence of four α‐genes. Hb O‐Arab was easily recognized through its electrophoretic properties and was confirmed by the suppression of the Eco RI site located in exon 3 of the β‐gene. The percentages of the various hemoglobins showed that the doubly mutated hemoglobin Dunn/O‐Arab has a normal stability and suggested that the Dunn mutation is carried by the α 1 ‐gene. In cord blood [propositus's son], the output of the α Dunn gene was found equivalent to that existing in the adult.