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Hemolytic uremic syndrome in a patient with small cell lung cancer
Author(s) -
Avvento Louis,
Gordon Sandra,
Silberberg Jeffrey M.,
Zarrabi M. Hosein,
Zucker Stanley
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830270314
Subject(s) - microangiopathic hemolytic anemia , medicine , dipyridamole , vincristine , hemolytic anemia , platelet , aspirin , lung , gastroenterology , thrombotic thrombocytopenic purpura , chemotherapy , cyclophosphamide
Hemolytic uremic syndrome is a rare entity in patients with carcinoma and presents with a triad of renal insufficiency, microangiopathic hemolytic anemia, and thrombocytopenia. We report this syndrome for the first time in a patient with small cell lung carcinoma. Spontaneous platelet aggregation of washed normal platelets was demonstrated using patient plasma. Circulating immune complex levels were not elevated. The entity completely resolved after treatment with plasma, vincristine, aspirin, and dipyridamole.