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Clonal trisomy 8 is associated with myeloid phenotype rather than the neoplastic transformation in acute leukemia
Author(s) -
Cassano William F.,
Hintz Marilyn S.
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830270307
Subject(s) - acute myelomonocytic leukemia , phenotype , myeloid , karyotype , neoplastic transformation , biology , trisomy , cancer research , myeloid leukemia , chromosome abnormality , immunology , transformation (genetics) , malignant transformation , leukemia , chronic myelomonocytic leukemia , trisomy 8 , genetics , bone marrow , myelodysplastic syndromes , chromosome , gene , carcinogenesis
Our studies of an acute leukemia with a clonal t(1;11) marker have demonstrated a conversion from pre‐B cell to myelomonocytic phenotype associated with the acquisition of trisomy 8. This finding suggests that trisomy 8, a frequent clonal abnormality in acute myeloid leukemias, may be associated with the myeloid phenotype rather than the neoplastic transformation. A permanent myelomonocytic cell line, designated UF‐SK1, has been established from leukemic cells with a 47,XX, + 8,t(1;11) (p31;q25) karyotype and shown to have myelomonocytic characteristics, including phorbol ester‐induced differentiation to macrophages. This new cell line will be a valuable tool in the study of leukemogenesis and lineage commitment.