Rapid response to 2′‐deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma | Zendy

Lembersky Barry C. | Zendy; Ratain Mark J. | Zendy; Westbrook Carol | Zendy; Golomb Harvey M. | Zendy

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Rapid response to 2′‐deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma

Author(s) -

Lembersky Barry C.,

Ratain Mark J.,

Westbrook Carol,

Golomb Harvey M.

Publication year - 1988

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830270114

Subject(s) - deoxycoformycin , hairy cell leukemia , medicine , pentostatin , hairy cell , alpha interferon , leukemia , alpha (finance) , immunology , interferon alfa , gastroenterology , interferon , surgery , adenosine , adenosine deaminase , construct validity , patient satisfaction

A patient with advanced hairy cell leukemia initially had a short‐lived minor response to interferon alpha therapy and failed to respond to interferon gamma. Subsequent treatment with 2′‐deoxycoformycin (dCF) administered biweekly for 12 wk resulted in a complete hematological remission which has continued for 16 months without additional therapy.

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