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Rapid response to 2′‐deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma
Author(s) -
Lembersky Barry C.,
Ratain Mark J.,
Westbrook Carol,
Golomb Harvey M.
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830270114
Subject(s) - deoxycoformycin , hairy cell leukemia , medicine , pentostatin , hairy cell , alpha interferon , leukemia , alpha (finance) , immunology , interferon alfa , gastroenterology , interferon , surgery , adenosine , adenosine deaminase , construct validity , patient satisfaction
A patient with advanced hairy cell leukemia initially had a short‐lived minor response to interferon alpha therapy and failed to respond to interferon gamma. Subsequent treatment with 2′‐deoxycoformycin (dCF) administered biweekly for 12 wk resulted in a complete hematological remission which has continued for 16 months without additional therapy.