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Translocation (3;21) in Philadelphia chromosome—positive chronic myelogenous leukemia prior to the onset of blast crisis
Author(s) -
Coyle Thomas,
Najfeld Vesna
Publication year - 1988
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830270113
Subject(s) - chromosomal translocation , blast crisis , chronic myelogenous leukemia , abnormality , philadelphia chromosome , bone marrow , leukemia , precursor cell , medicine , immunology , pathology , biology , genetics , cell , psychiatry , gene
Two female patients in the chronic phase of CML were found to have, in addition to t(9;22), a new karyotypic abnormality—t(3;21)(q26;q22)—present in bone marrow cells. At diagnosis, this abnormality was observed in a small number of marrow cells in both patients, and as the disease progressed in patient 1, the percentage of cells showing t(3;21) was increased, reaching 100% as the transformation to blast crisis occurred. These observations suggest that t(3;21) may represent a new and rare nonrandom rearrangement which may be identified prior to the onset of blast crisis.