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Platelet kinetics in human immunodeficiency virus induced thrombocytopenia
Author(s) -
BelAli Zoher,
Dufour Valérie,
Najean Yves
Publication year - 1987
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830260402
Subject(s) - splenectomy , platelet , serology , medicine , human immunodeficiency virus (hiv) , immunology , virus , virology , antibody , spleen
Abstract A platelet kinetic study was performed in 34 patients (33 homosexuals and/or drug addicts) with (in most of them) severe and isolated thrombocytopenia and human immunodeficiency virus positive serological tests. The reported data indicate that the thrombocytopenia is due to an extracorpuscular hyperdestruction. The sequestration of the labeled platelets is exclusively splenic in most of the cases. Splenectomy was successful in the ten cases in which it was done; however, corticoids showed no or low effect, and Ig‐G infusion had only a temporary efficacy.