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Excess HLA antigens after transfusion of sickle cell patient with AIDS
Author(s) -
Castro Oswaldo,
Alarif Lamya,
Saxinger Carl,
Frederick Winston
Publication year - 1987
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830260309
Subject(s) - human leukocyte antigen , immunology , medicine , antigen , disease
A woman with sickle cell‐hemoglobin C disease developed the acquired immunodeficiency syndrome (AIDS), possibly as the result of blood transfusions administered 4 years earlier. Three months after subsequent transfusions, she had excess HLA‐A and DR antigens (triplets) on her circulating lymphocytes. Three of her first‐degree relatives were HLA‐typed, and none had excess antigens. Family studies also indicated that the patient had at least one HLA‐A antigen that was probably not inherited. These findings suggest the possibility that transient hemopoietic engraftment can occur in transfused sickle cell patients with AIDS.