A possible mechanism of increased sodium influx in red cells with abnormal membrane lipid levels induced by phospholipase A 2 | Zendy

Hashimoto Masashi | Zendy; Yawata Yoshihito | Zendy

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A possible mechanism of increased sodium influx in red cells with abnormal membrane lipid levels induced by phospholipase A 2

Author(s) -

Hashimoto Masashi,

Yawata Yoshihito

Publication year - 1987

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830260103

Subject(s) - sodium , phospholipase , membrane , choline , phospholipase c , calcium , chemistry , albumin , cell membrane , biochemistry , phospholipase a2 , membrane transport , biophysics , medicine , endocrinology , biology , enzyme , organic chemistry

Membrane transport—sodium (Na + ) influx and calcium (Ca 2+ ) uptake—was examined in human mature red cells treated with phospholipase A 2 (PLase A 2 ) from snake venom. PLase A 2 ‐induced conversion of phosphatidyl choline (PC) to lysophosphatidyl choline (L‐PC) was associated with a marked increase in Na + influx and Ca 2+ uptake. After L‐PC was removed from the cell membrane of the PLase A 2 ‐treated red cells in the presence of albumin, an additional increase in Ca 2+ transport was observed. These results indicate that membrane lipid abnormalities, such as increased L‐PC and/or a loss of total lipids, appear to induce increased membrane transport.

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