Premium
Modulation of monocyte Mo2 surface antigen expression by exposure to respiratory syncytial virus
Author(s) -
Baumann M. A.,
Paul C. C.,
Stokes C.,
Bernstein J. M.
Publication year - 1987
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830250314
Subject(s) - antigen , monoclonal antibody , respiratory system , monocyte , epitope , virus , virology , biology , antibody , immunology , anatomy
The Mo2 antibody recognizes a monocyte‐specific cell surface antigen of unknown function. Upward modulation of Mo2 surface epitope density was demonstrated in response to 72‐hr culture of monocytes with respiratory syncytial vcirus (RSV), but this was not seen after culture with phytohemagglutinin or other respiratory viruses. Monoclonal antibody probes for RSV proteins were used to demonstrate probable replication of RSV proteins in peripheral blood monocytes and pulmonary alveolar macrophages. These data provide possible clues to the biologic role of the Mo2 antigen.