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Immunological aspects of the anemia of rheumatoid arthritis
Author(s) -
Sugimoto Masakuni,
Wakabayashi Yoshihisa,
Hirose ShunIchi,
Takaku Fumimaro
Publication year - 1987
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830250102
Subject(s) - rheumatoid arthritis , concomitant , medicine , peripheral blood , immunology , anemia , bone marrow , endocrinology
In order to investigate the cause of the anemia concomitant with rheumatoid arthritis (RA), we examined, using the erythroid colony assay of human bone marrow colonyforming units‐erythroid (CFU‐e) and burst‐forming units‐erythroid (BFU‐e), the effects of the patients' serum and peripheral blood T lymphocytes on the CFU‐e‐derived colonies. The counts of erythroid colonies of RA patients were markedly lower than those of human control subjects [CFU‐e: control 152.9 ± 30.6 (n = 19), RA 51.1 ± 13.6 (n = 7), t = 7.66567, p < 0.01; BFU‐e: control 25.2 ± 5.9 (n = 5), RA 12.6 ± 2.6 (n = 7), t = 4.574, p < 0.01]. The serum from two out of seven RA patients slightly inhibited the formation of CFU‐e‐derived colonies of human control subjects (t = 2.31, 0.05 < p < 0.1); however, the serum from the other five RA patients did not significantly inhibit human control erythroid colony formation as compared with human control serum (t = 0.981, 0.3 < p < 0.4). On the other hand, peripheral blood T lymphocytes of the patients markedly inhibited the formation of CFU‐e‐derived colonies of the control subjects (t = 4.24, p > 0.01). The above‐mentioned results suggest that the peripheral blood T lymphocytes of RA patients might play a role as one of the causes of the concomitant anemia of RA patients.