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Hematological aspect of Rh deficiency syndrome: A case report and a review of the literature
Author(s) -
Nash R.,
Shojania A. M.
Publication year - 1987
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830240306
Subject(s) - splenectomy , erythrocyte fragility , red cell , medicine , hemolytic anemia , anemia , red blood cell , spleen , immunology , gastroenterology , hemolysis , pediatrics
The hematological aspects of the original case of Rh mod are reported. The subject, as in other reported cases, had a chronic hemolytic anemia characterized by stomatocytosis, reduced osmotic fragility, and abnormal autohemolysis correctable with the addition of glucose. The 51 Cr red cell survival studies showed the spleen to be the preferential site of red cell destruction and splenectomy produced a dramatic improvement in red cell survival. The topic of Rh deficiency syndrome (Rh null and Rh mod ) is briefly reviewed with regard to the number of cases reported, to genetic aspects, to the hematological findings, and to the results of splenectomy.