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Restoration of decreased suppressor cells by vitamin B 12 therapy in a patient with pernicious anemia
Author(s) -
Kubota Kazuo,
Arai Toshimasa,
Tamura Jun'Ichi,
Shirakura Takuo,
Morita Toyoho
Publication year - 1987
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830240214
Subject(s) - pernicious anemia , vitamin b12 , anemia , medicine , pathogenesis , vitamin b , intrinsic factor , hematinic , lymphocyte , vitamin , immunology , gastroenterology
A unique case of pernicious anemia is described. Initially, the percentage of OKT8‐positive blood cells was markedly decreased, resulting in an increase in the OKT4/OKT8 ratio. The level of OKT8‐positive blood cells was, however, returned to normal after vitamin B 12 therapy. The finding may propose a possible role of the imbalance of blood lymphocyte subpopulations on the pathogenesis of pernicious anemia and also a responsibility of vitamin B 12 for such a selective reduction in the OKT8‐positive blood cells.