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An autoantibody with poten antithrombin activity whose action could be inhibited by toluidine blue or methylene blue
Author(s) -
Shojania A. Majid,
Meilleur Gisele,
Alvi Abdul W.
Publication year - 1987
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830240212
Subject(s) - methylene blue , toluidine , antithrombin , action (physics) , autoantibody , blue light , medicine , chemistry , endocrinology , heparin , immunology , antibody , biochemistry , organic chemistry , catalysis , physics , quantum mechanics , optics , photocatalysis
A 41‐year‐old man with posthepatitic liver cirrhosis and bleeding tendency was found to have a circulating anticoagulant with potent antithrombin activity. The thrombin time of the patient's purified fibrinogen was normal. This anticoagulant was residing in the patient's IgG fraction, and his IgG fraction could prolong the thrombin time of purified fibrinogen, suggesting that this circulating anticoagulant was an antibody. No heparin was detected in the patient's plasma. However, the antithrombin activity of this anticoagulant could be neutralized by toluidine blue or methylene blue ex vivo.