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Leu 7 + , Leu 11a − acute T‐lymphoblastic leukemia having low K cell activity and NO NK cell activity
Author(s) -
Falcäo Roberto P.,
Ismael Sebastiäo J.
Publication year - 1987
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830240113
Subject(s) - lymphoblastic leukemia , t cell , leukemia , immunology , t lymphocyte , precursor cell , microbiology and biotechnology , biology , antigen , cell , genetics , immune system
The phenotypic and functional features of the leukemic blasts from a child with Tacute lymphoblastic leukemia (T‐ALL) were studied. The leukemic cells lacked the usual markers of T‐cell lineage (T 3 − , T 11 − , E‐sheep − ) although they displayed some T‐lymphocyte markers (T 6 + , T 8 + , T 9 + , T 10 + ) and were T γ − . Furthermore, these cells had a strong reaction with anti‐Leu 7 but were negative to anti‐leu 11a antibody and exhibited low K cell activity, no NK activity, and showed virtually no response to PHA. These leukemic cells probably represented the leukemic counterpart of the Leu 7 + , Leu 11a − subset that has been demonstrated in the peripheral blood of normal individuals.