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Eosinophilic fibrohistiocytic lesion of bone marrow associated with monoclonal gammopathy and osteolytic lesions
Author(s) -
Nagler A.,
BenArieh Y.,
Brenner B.,
Tatarsky I.,
Pollack S.
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830230312
Subject(s) - medicine , pathology , bone marrow , multiple myeloma , monoclonal gammopathy of undetermined significance , lesion , eosinophilic , plasmacytoma , monoclonal , gammopathy , bone marrow examination , monoclonal antibody , immunology , antibody
We describe a 63‐year‐old male patient with severe osteoporosis, multiple lytic bone lesions, and monoclonal gammopathy (IgGλ). Whereas the tentative diagnosis in this case was multiple myeloma, bone marrow trephine biopsies of the iliac crest and from an osteolytic lesion of the tibia both showed a peculiar infiltrate consisting of numcrous clongated mast cells, eosinophils, and some plasma cells and lymphocytes. The bone marrow lesions fit the diagnosis of eosinophilic fibrohistiocytic lesion of bone marrow (EFHBM). The patient had no abnormality that could be related to a known allcrgic disease, and no relationship to drug hypersensitivity could be established. The features of the bone marrow infiltrate and its association with monoclonal gammopathy may suggest a linkage between EFHBM and the monoclonal gammopathy.