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Increased fibrinolytic activity in patients undergoing cardiopulmonary bypass operation
Author(s) -
Kucuk Omer,
Kwaan Hau C.,
Frederickson James,
Wade Leonard,
Green David
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830230306
Subject(s) - cardiopulmonary bypass , medicine , extracorporeal circulation , fibrinolysis , cardiology , artery , coronary artery bypass surgery , extracorporeal , surgery , anesthesia
The influence of cardiopulmonary bypass on fibrinolytic activity was assessed by a sensitive clot lysis assay in eight patients undergoing coronary artery bypass operations. Fibrinolytic activity increased immediately after cardíopulmonary bypass was begun and remained elevated throughout the period of extracorporeal circulation. At the conclusion of the operative procedure, fibrinolytic activity returned to the normal range in all patients, and no subject had postoperative bleeding.