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Prednisone stimulation of erythropoiesis in leukemic children during remission
Author(s) -
Amylon Michael D.,
Perrlne Susan P.,
Glader Bertil E.
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830230213
Subject(s) - erythropoiesis , prednisone , medicine , stimulation , pediatrics , anemia
Children with acute leukemia in remission manifest reticulocytosis and a significant increase in hemoglobin concentration (mean increment of 2.3 ± 1.1 g/d 1) following prednisone pulse therapy. This hemoglobin increment is not associated with changes in serum erythropoietin activity. It is speculated that this stimulation of red cell production may be a direct effect of steroids on erythroid progenitor cells.