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Philadelphia‐positive metaphases in the marrow after bone marrow transplantation for chronic granulocytic leukemia
Author(s) -
Apperley Jane F.,
Rassool Feyruz,
Parreira Antonio,
Geary Colin G.,
Harrison Christine,
Stansfield Derek,
Goldman John M.
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830220211
Subject(s) - leukemia , lymphocytosis , bone marrow , medicine , transplantation , chronic granulocytic leukemia , bone marrow transplantation , immunology , pathology
A 28‐year‐old man with Ph‐positive chronic granulocytic leukemia (CGL) was treated by high‐dose chemoradiotherapy and transplantation of marrow cells harvested from his HLA‐identical brother. One year after bone marrow transplantation (BMT) examination of his marrow showed a minority population of Ph‐positive cells; their proportion subsequently fell such that 2 years after transplant analysis of marrow cells showed only cytogenetically normal cells. The patient remains clinically normal with a persisting mild lymphocytosis but without hematological evidence of leukemia. We cannot in this patient distinguish between persisting leukemia that later could no longer be recognized and relapse of leukemia that is now suppressed, perhaps only temporarily. This case emphasizes the need for caution in interpreting chromosomal finding after BMT for CGL.