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Primary amyloidosis (AL) in families
Author(s) -
Gertz Morie A.,
Garton John P.,
Kyle Robert A.
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830220210
Subject(s) - amyloidosis , al amyloidosis , monoclonal gammopathy of undetermined significance , medicine , waldenstrom macroglobulinemia , multiple myeloma , macroglobulinemia , paraproteinemias , monoclonal , immunology , pathology , dermatology , antibody , immunoglobulin light chain , monoclonal antibody , lymphoma
We report the occurrence of immunoglobulin‐related amyloidosis (AL) in three separate families, each family having two members affected. None of the six patients had evidence to suggest the presence of familial amyloidosis (AF). Previously, immunoglobulin‐related amyloidosis (AL) was considered to be a sporadic disease process. Because of the occasional familial occurrence of other monoclonal gammopathies such as monoclonal gammopathy of undetermined significance, multiple myeloma, and macroglobulinemia of Waldenström, amyloidosis (AL) should be added to the list of immunopathies with a familial predisposition.