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Multimeric pattern discrepancy between platelet and plasma von Willebrand factor in type IIC von Willebrand disease
Author(s) -
Batlle J.,
Fernandez M. F. Lopez,
Villamor A. Fernandez,
Berges C. Lopez,
Zimmerman T. S.
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830220113
Subject(s) - von willebrand factor , von willebrand disease , platelet , medicine , platelet lysate , plasma levels , immunology , chemistry
von Willebrand factor (vWF) from platelet lysate and plasma, collected in the presence of protease inhibitors, was studied in two patients with type IIC von Willebrand disease (vWD). Platelet and plasma vWF showed the smallest multimer increased, but the latter had a repeating single band whereas the former had a repeating “doublet.” This platelet‐plasma discrepancy observed for the first time in these patients suggests that the repeating “doublet” or single band described in other type IIC patients represent minor subgroups of type IIC vWD.