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Association of HLA and autoantibody in transfused sickle cell disease patients
Author(s) -
Ofosu Mildred D.,
Saunders David A.,
Dunston Georgia M.,
Castro Oswaldo,
Alarif Lamya
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830220105
Subject(s) - autoantibody , anti nuclear antibody , medicine , immunology , rheumatoid factor , incidence (geometry) , human leukocyte antigen , antibody , histocompatibility , disease , antigen , physics , optics
This study evaluates autoantibody production in sickle cell disease patients and determines whether genes in the major histocompatibility complex are associated with autoantibody responses. Rheumatoid factor was significantly increased for both male and female patients and was less prevalent in highly transfused patients. Significant increases were also detected in the incidences of antinuclear antibody for females and antismooth muscle antibody for males. Low incidence of antinuclear antibody was significantly associated with HLA‐DR3. Significant associations were also found between the incidence of antinuclear antibody and both HLA‐A28 and B15.