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Vitamin E consumption by human blood platelets activated by latex particles
Author(s) -
Principe Domenico Del,
Menichelli Adriana,
Lubrano Riccardo,
Bandino Donatella,
Giulio Stefano Di,
Di Corpo Maria Luisa,
Giardini Omero
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830210403
Subject(s) - platelet , cyanide , potassium cyanide , human blood , catalase , vitamin , chemistry , azide , potassium , biochemistry , medicine , endocrinology , oxidative stress , inorganic chemistry , physiology , organic chemistry
Human blood platelet activation elicited by latex particles is associated to a 30% decrease in the cellular content of vitamin E. The vitamin E consumption is inhibited by the addition of catalase (500 U/ml) and azide (1 mM), but it is not affected by potassium cyanide (1 mM). It may be proposed that the challenge of platelets with particulate stimuli causes generation of oxygen reduction products, which leads to vitamin E depletion.