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Nuclear bridging of erythroblasts in acquired dyserythropoiesis: An early and transient preleukemic marker
Author(s) -
Bethlenfalvay Nicholas C.,
Phaure T. A. J.,
Phyliky Robert L.,
Bowman Robert P.
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830210311
Subject(s) - preleukemia , leukemia , refractory anemia , dysplasia , erythroblast , bone marrow , medicine , anemia , pathology , erythropoiesis , acute leukemia , myelodysplastic syndromes , immunology
The clinical, hematologic, and histological characteristics of two patients who progressed from refractory anemia to acute leukemia are described. When first studied, nuclear bridging of erythroblasts, similar to that seen in congenital dyserythropoietic anemia type I and megakaryocytic dysplasia, were the only abnormalities. Within 6 years, both patients died, the first of acute nonlymphocytic leukemia, the second of erythroleukemia. Nuclear bridging of erythroblasts in the marrrow of these patients was an early and transient phenomenon and was not observed during the terminal phase of leukemia.