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Slow infusion of vincristine in the treatment of idiopathic thrombocytopenic purpura
Author(s) -
Manoharan Arumugam
Publication year - 1986
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830210203
Subject(s) - medicine , vincristine , thrombocytopenic purpura , platelet , purpura (gastropod) , splenectomy , surgery , anesthesia , chemotherapy , cyclophosphamide , spleen , biology , ecology
Ten patients with idiopathic thrombocytopenic purpura (ITP) were treated wtih vincristine (VCR), given as a slow infusion over a 4‐hr period, at weekly intervals for 4 weeks. The VCR therapy achieved a sustained recovery of platelet count in five patients with ITP of 2 weeks to 5 months duration; a transient recovery was observed in four patients with ITP of 6 months to 5 years duration. Therapy had no effect at all in one patient who had ITP of 10 years duration. Vincristine therapy appears to be therapeutically more beneficial when given as a slow infusion and can achieve sustained recovery of platelet count in patients with ITP of less than six months duration.